Faculty Collaboration Database

Polymorphisms in alternative splicing associated genes are associated with lung cancer risk in a Chinese population. Lung Cancer 2015 Sep;89(3):238-42

Date

07/15/2015

Pubmed ID

26162562

DOI

10.1016/j.lungcan.2015.06.010

Scopus ID

2-s2.0-84938741242 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

BACKGROUND: Alternative splicing is an important biological step during mRNA processing. Misregulation of alternative splicing can produce aberrant protein isoforms, thus contributing to cancer. We hypothesized that variants in 5 critical splicing factor-associated genes might play an important role in carcinogenesis of lung cancer.

MATERIALS AND METHODS: A case-control study including 1,341 non-small cell lung cancer (NSCLC) cases and 1,982 cancer-free controls were conducted to evaluate the associations of 16 tagging/functional polymorphisms in 5 splicing factor-associated genes with lung cancer risk.

RESULTS: We found altogether 8 SNPs were associated with lung cancer risk with adjustment of age, gender, and smoking status after multiple corrections (FDR). Among these, six SNPs were related with SRSF7(rs10197412, OR (95% CI)=1.23 (1.06-1.43), P for FDR=0.018; rs12621103, OR(95% CI)=1.25 (1.08-1.46), P for FDR=0.016; rs13024811, OR (95% CI)=1.25 (1.07-1.46), P for FDR=0.016; rs2037875, OR (95% CI)=1.23 (1.06-1.42), P for FDR=0.018; rs3134628, OR (95% CI)=1.25(1.07-1.45), P for FDR=0.016 and rs6715866, OR (95% CI)=1.23 (1.07-1.43), P for FDR=0.016); one SNP was near PTBP2 (rs12566237: OR (95% CI)=1.16 (1.05-1.28), P for FDR=0.016) and one SNP in HNRNPQ (rs16876385: OR (95% CI)=1.17 (1.04-1.32), P for FDR=0.022).

CONCLUSIONS: Our findings indicated that genetic variants in these splicing-associated genes might modify individual susceptibility to lung cancer in Chinese population. Further large-scale well-formed population studies and functional researches are warranted to confirm our findings.

Author List

Shen W, Yin R, Wang C, Zhu M, Zhou W, Qin N, Sun J, Liu J, Dong J, Jin G, Ma H, Hu Z, Shen H, Xu L, Dai J

Author

Jing Dong PhD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Alleles
Alternative Splicing
Case-Control Studies
China
Female
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk