Genetic susceptibility to multiple sclerosis: a linkage analysis with age-of-onset corrections. Clin Genet 1980 Sep;18(3):160-7
Date
09/01/1980Pubmed ID
7438496DOI
10.1111/j.1399-0004.1980.tb00864.xScopus ID
2-s2.0-0018956605 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
To test the hypothesis that a multiple sclerosis susceptibility (MSS) gene is linked to the HLA loci, formal linkage analysis was conducted on 40 multiplex families, 20 each from the Seattle and Los Angeles areas. The computer program LIPED was utilized. A dominant model of inheritance was assumed. Penetrance values of 0.05, 0.35, and 0.67 were entered into the analyses, and an age-of-onset correction was incorporated. The resulting lod scores were supportive of linkage at the lower penetrance levels. The maximum lod score, 2.411, at an estimated recombination fraction of 0.10 in both males and females, was generated at a penetrance value of 0.05. With a penetrance value of 0.67, the lod scores did not support linkage. Under an autosomal dominant model of inheritance, the results were supportive of linkage when the presumed penetrance of the MSS gene is low. The results also confirmed the importance of incorporating an age-of-onset correction into linkage analyses.
Author List
Haile RW, Hodge SE, Visscher BR, Spence MA, Detels R, McAuliffe TL, Park MS, Dudley JPAuthor
Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Age FactorsComputers
Disease Susceptibility
Female
Genes, Dominant
Genetic Linkage
HLA Antigens
Humans
Male
Multiple Sclerosis
Pedigree
Recombination, Genetic
