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Racial and Ethnic Variation Associated With Human Papillomavirus Genotype in Anal Dysplasia. J Surg Res 2020 12;256:311-316

Date

07/28/2020

Pubmed ID

32712446

DOI

10.1016/j.jss.2020.06.047

Scopus ID

2-s2.0-85088388259   1 Citation

Abstract

BACKGROUND: Human Papillomavirus (HPV) is known to cause dysplasia and cancer. In cervical disease, there are documented differences in prevalence of HPV genotypes among racial/ethnic groups. Little is known about prevalence of HPV genotypes in anal dysplasia. This study aimed to evaluate association between HPV genotypes and race/ethnicity in a racially heterogenous population with anal dysplasia.

METHODS: This was a single-institution retrospective review of patients treated for anal dysplasia between 2008 and 2019. HPV genotype, obtained via anal swab testing, was recorded as HPV 16, HPV 18, or other non-16/18 high-risk (HR) HPV genotypes. Univariate and multivariate logistic regression analyses were used to evaluate the association between patient factors and HPV genotype.

RESULTS: Of 517 patients meeting inclusion criteria, 46.8% identified as White, 37.1% as Black, 13.2% as Hispanic, and 2.9% as other/unknown. Race/ethnicity (P = 0.016) and sex (P < 0.001) were significantly associated with differences in prevalence of HPV genotypes. Black (odds ratio 1.56, 95% confidence interval 1.00-2.44) and male (odds ratio 2.35, 95% confidence interval 1.42-3.92) patients were significantly more likely to have non-16/18 HR HPV genotypes.

CONCLUSIONS: In a racially and socioeconomically diverse cohort of patients with anal dysplasia, Black race and male sex were associated with increased likelihood of infection with a non-16/18 HR HPV genotype. Many of these genotypes are not covered by currently available vaccines. Further study is warranted to evaluate anal HPV genotypes in a larger cohort, as this may have important implications in HPV vaccination and anal dysplasia screening efforts.

Author List

Mather TL, Hu KY, Rein LE, Szabo A, Lundeen SJ, Peterson CY, Ludwig KA, Ridolfi TJ

Authors

Kirk A. Ludwig MD Chief, Professor in the Surgery department at Medical College of Wisconsin
Sarah J. Lundeen NP Nurse Practitioner Surgical in the Surgery department at Medical College of Wisconsin
Carrie Peterson MD, MS, FACS, FASCRS Associate Professor in the Surgery department at Medical College of Wisconsin
Timothy J. Ridolfi MD Associate Professor in the Surgery department at Medical College of Wisconsin
Aniko Szabo PhD Professor in the Institute for Health and Equity department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
African Americans
Alphapapillomavirus
Anal Canal
Anus Neoplasms
Asian Americans
DNA, Viral
European Continental Ancestry Group
Female
Genotyping Techniques
Hispanic Americans
Humans
Male
Mass Screening
Middle Aged
Oceanic Ancestry Group
Papillomavirus Infections
Papillomavirus Vaccines
Retrospective Studies
Risk Factors
Sex Factors
Socioeconomic Factors
Wisconsin