Evaluation of lithium therapy for alcoholism. J Clin Psychiatry 1984 Dec;45(12):494-9
Date
12/01/1984Pubmed ID
6389520Scopus ID
2-s2.0-0021718345 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
The efficacy of lithium therapy for alcoholism was examined in 84 alcoholic volunteers admitted for rehabilitation. Subjects were randomly assigned to a lithium or placebo treatment condition for 18 months, and were reinterviewed monthly to document their compliance, drinking status, and mood. Two separate factors contributed to abstinent outcome: therapeutic serum lithium levels (greater than or equal to 0.4 mEq/L) and medication compliance. Recommendations are proposed for studying compliance effects in future treatment studies.
Author List
Fawcett J, Clark DC, Gibbons RD, Aagesen CA, Pisani VD, Tilkin JM, Sellers D, Stutzman DAuthor
David C. Clark PhD Assistant Dean, Professor in the Research Office department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAlcoholism
Clinical Trials as Topic
Depressive Disorder
Female
Humans
Lithium
Male
Middle Aged
Patient Compliance
Placebos
Psychiatric Status Rating Scales
Random Allocation
Recurrence