Faculty Collaboration Database

Fatiguing exercise attenuates pain-induced corticomotor excitability. Neurosci Lett 2009 Mar 13;452(2):209-13

Date

04/23/2009

Pubmed ID

19383441

DOI

10.1016/j.neulet.2009.01.038

Scopus ID

2-s2.0-60249103229 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

The purpose of this study was to assess net corticomotor excitability during a painful stimulus before and after exercise. In the first study, 25 subjects participated in three sessions: one familiarization session and two experimental sessions. The two experimental sessions were randomized and involved measurement of pain perception before and after (1) a submaximal isometric fatiguing contraction with the left elbow flexor muscles and (2) 30 min of quiet rest. Pain perception was assessed using a pressure device applied to the right index finger for 2 min. Motor evoked potentials (MEPs) of the left brachioradialis muscle were measured following transcranial magnetic stimulation (TMS) which was delivered before, during, and after the 2 min pain test. In the second study, 12 subjects participated in one session which involved application of TMS to elicit MEPs at the same time points as in study one, before and after a submaximal fatiguing contraction, but in the absence of pain. In the absence of the mechanical noxious stimulus, MEP amplitude was reduced following the fatiguing contraction and unchanged over this time period. In study one, pain threshold increased and pain ratings decreased following the isometric contraction but not after 30 min of quiet rest. During application of the mechanical noxious stimulus to the right index finger, MEP amplitude of the left brachioradialis muscle increased indicating an increase in net corticomotor excitability. The pain-induced increase in MEPs was attenuated following the isometric fatiguing contraction and this occurred in parallel with the decrease in pain.

Author List

Hoeger Bement MK, Weyer A, Hartley S, Yoon T, Hunter SK

Author

Marie Hoeger Bement MPT,PhD Associate Professor in the Physical Therapy department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Analgesia
Down-Regulation
Evoked Potentials, Motor
Exercise
Exercise Therapy
Female
Humans
Male
Motor Cortex
Muscle Contraction
Muscle Fatigue
Muscle, Skeletal
Pain
Pain Management
Pain Measurement
Pain Threshold
Physical Stimulation
Pyramidal Tracts
Transcranial Magnetic Stimulation
Young Adult