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Fetal diagnosis of KCNQ1-variant long QT syndrome using fetal echocardiography and magnetocardiography. Pacing Clin Electrophysiol 2020 Apr;43(4):430-433

Date

03/14/2020

Pubmed ID

32168391

Pubmed Central ID

PMC7166171

DOI

10.1111/pace.13900

Scopus ID

2-s2.0-85082933653 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

A pregnant woman with KCNQ1 variant long QT syndrome (LQTS) underwent fetal magnetocardiography (fMCG) after atrioventricular (AV) block was noted during fetal echocardiogram-atypical for LQTS type 1. Concern for fetal LQTS on fMCG prompted monitoring of maternal labs, change of maternal beta blocker therapy, and frequent fetal echocardiograms. Collaboration between obstetricians, neonatologists, and pediatric cardiologists ensured safe delivery. Beta blocker therapy was initiated after birth, and postnatal evaluation confirmed genotype and phenotype positive LQTS in the infant. Our experience suggests diagnosis and evaluation of fetal LQTS can alter antenatal management to reduce risk of poor fetal and postnatal outcomes.

Author List

Desai L, Wakai R, Tsao S, Strasburger J, Gotteiner N, Patel A

Author

Janette F. Strasburger MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Echocardiography
Female
Humans
KCNQ1 Potassium Channel
Long QT Syndrome
Magnetocardiography
Pregnancy
Prenatal Diagnosis