Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study. Diabetes 2018 Jan;67(1):155-164
Date
11/01/2017Pubmed ID
29084784Pubmed Central ID
PMC5741150DOI
10.2337/db16-1229Scopus ID
2-s2.0-85038897497 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Over the past 20 years, a large body of experimental and epidemiologic evidence has linked sleep duration and quality to glucose homeostasis, although the mechanistic pathways remain unclear. The aim of the current study was to determine whether genetic variation influencing both sleep and glucose regulation could underlie their functional relationship. We hypothesized that the genetic regulation of electroencephalographic (EEG) activity during non-rapid eye movement sleep, a highly heritable trait with fingerprint reproducibility, is correlated with the genetic control of metabolic traits including insulin sensitivity and β-cell function. We tested our hypotheses through univariate and bivariate heritability analyses in a three-generation pedigree with in-depth phenotyping of both sleep EEG and metabolic traits in 48 family members. Our analyses accounted for age, sex, adiposity, and the use of psychoactive medications. In univariate analyses, we found significant heritability for measures of fasting insulin sensitivity and β-cell function, for time spent in slow-wave sleep, and for EEG spectral power in the delta, theta, and sigma ranges. Bivariate heritability analyses provided the first evidence for a shared genetic control of brain activity during deep sleep and fasting insulin secretion rate.
Author List
Morselli LL, Gamazon ER, Tasali E, Cox NJ, Van Cauter E, Davis LKAuthor
Lisa Morselli MD, PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdiposityAdult
Blood Glucose
Brain
Electroencephalography
Female
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Pedigree
Sleep
