Impact of low fasting plasma glucose on mortality in the general population. Diab Vasc Dis Res 2020;17(3):1479164120930599
Date
07/29/2020Pubmed ID
32720509Pubmed Central ID
PMC7607395DOI
10.1177/1479164120930599Scopus ID
2-s2.0-85087131564 (requires institutional sign-in at Scopus site) 1 CitationAbstract
BACKGROUND: While the association between hypoglycaemia and poor outcomes in diabetes is well established, it is unclear whether such an association is generalizable to those without diabetes.
METHODS: A total of 8497 participants free of cardiovascular disease and diabetes from the Third National Health and Nutrition Examination Survey were included. We examined the relationship between baseline low (<80 mg/dL) and high (⩾126 mg/dL) fasting plasma glucose compared to normal levels (80-99 mg/dL).
RESULTS: Over a median follow-up of 14 years, 2101 deaths occurred, of which 570 were due to cardiovascular disease. In a model adjusted for sociodemographic and cardiovascular disease risk factors, individuals with low fasting plasma glucose were at increased risk of cardiovascular disease and all-cause mortality [hazard ratio = 1.79 (95% confidence interval = 1.04-3.08) and hazard ratio = 1.35 (95% confidence interval = 1.02-1.78), respectively], compared to those with normal fasting plasma glucose. These associations were stronger among men than women for both cardiovascular disease mortality and all-cause mortality.
CONCLUSION: Low fasting plasma glucose in individuals without diabetes is a risk factor for cardiovascular disease and all-cause mortality, especially in men.
Author List
Chevli PA, Ahmad MI, Hari K, Anees MA, Soliman EZAuthor
Muhammad Imtiaz Ahmad MBBS Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Biomarkers
Blood Glucose
Cardiovascular Diseases
Cause of Death
Fasting
Female
Humans
Hypoglycemia
Male
Middle Aged
Nutrition Surveys
Prognosis
Risk Assessment
Risk Factors
Sex Factors
Time Factors
United States
Young Adult
