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Reduction in myocardial infarct size by the new potassium channel opener bimakalim. J Cardiovasc Pharmacol 1994 Apr;23(4):554-61

Date

04/01/1994

Pubmed ID

7516004

DOI

10.1097/00005344-199404000-00006

Scopus ID

2-s2.0-0028202074   34 Citations

Abstract

We examined the effect of a new potassium channel opener, bimakalim, on myocardial infarct size (IS) in dogs. Barbital-anesthetized dogs were subjected to 90 min of left circumflex coronary artery (LCX) occlusion followed by 5-h reperfusion. Bimakalim (3 micrograms/kg bolus followed by 0.1 microgram/kg/min intravenously, i.v.) was initiated either 15 min before LCX occlusion and continued throughout the experiments in one group of animals or initiated 5 min before and throughout reperfusion in a second group. A third group of dogs received i.v. vehicle (control) 15 minutes before LCX occlusion and throughout the remainder of the experiment. IS was determined by triphenyltetrazolium histochemical staining, regional myocardial blood flow (RMBF) by the radioactive microsphere technique, and neutrophil migration by measurement of tissue myeloperoxidase (MPO) activity. Bimakalim reduced mean aortic blood pressure (MBP, 25 mm Hg) during the occlusion and reperfusion periods in the group of dogs that received the drug throughout the experiment and reduced in BP, during reperfusion when administered immediately before the reperfusion period. In addition, bimakalim increased LCX coronary artery blood flow (CBF) and increased regional myocardial blood flow (RMBF) primarily during reperfusion in both drug-treated groups, with the greatest increase to the subepicardial region. During occlusion, however, bimakalim had no effect on collateral blood flow to the ischemic region. In all three groups, left ventricular (LV) mass, area at risk (AAR) mass, and percentage of he left ventricle at risk were similar.(ABSTRACT TRUNCATED AT 250 WORDS)

Author List

Auchampach JA, Gross GJ

Author

John A. Auchampach PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Benzopyrans
Cell Movement
Coronary Circulation
Dihydropyridines
Dogs
Female
Hemodynamics
Male
Myocardial Infarction
Neutrophils
Potassium Channels
Regional Blood Flow
Vasodilator Agents
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0