Faculty Collaboration Database

The membrane-associated form of cyclin D1 enhances cellular invasion. Oncogenesis 2020 Sep 18;9(9):83

Date

09/20/2020

Pubmed ID

32948740

Pubmed Central ID

PMC7501870

DOI

10.1038/s41389-020-00266-y

Scopus ID

2-s2.0-85091177817 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

The essential G₁-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G₁-S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1^NL), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1^MEM) induced transwell migration and the velocity of cellular migration. The cyclin D1^MEM was sufficient to induce G₁-S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1^MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.

Author List

Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG

Author

Yunguang Sun MD, PhD Assistant Professor in the Pathology department at Medical College of Wisconsin