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Effect of direct thrombin inhibition with Bivalirudin (Hirulog) on restenosis after coronary angioplasty. Am J Cardiol 1998 Aug 15;82(4):511-5

Date

09/02/1998

Pubmed ID

9723642

DOI

10.1016/s0002-9149(98)00371-3

Scopus ID

2-s2.0-0031848588   30 Citations

Abstract

The direct antithrombin, bivalirudin, did not reduce angiographic restenosis measured either as the dichotomous restenosis rate of 62% for bivalirudin and 58% for heparin (p = 0.70), or as the late loss in lumen diameter of 0.44 +/- 0.47 mm for bivalirudin and 0.39 +/- 0.53 mm for heparin (p = 0.62). Direct thrombin inhibition with bivalirudin neither reduces angiographic restenosis nor alters the impact of several established risk factors for restenosis.

Author List

Burchenal JE, Marks DS, Tift Mann J, Schweiger MJ, Rothman MT, Ganz P, Adelman B, Bittl JA

Author

David S. Marks MD Vice Chair, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Angioplasty, Balloon, Coronary
Antithrombins
Coronary Disease
Female
Heparin
Hirudin Therapy
Hirudins
Humans
Linear Models
Male
Middle Aged
Peptide Fragments
Radiography
Recombinant Proteins
Recurrence
Risk Factors
Treatment Outcome