Faculty Collaboration Database

Measurement properties of Patient Reported Outcomes Measurement Information System domains for children with type 1 diabetes. Pediatr Diabetes 2021 Mar;22(2):335-344

Date

10/08/2020

Pubmed ID

33026680

Pubmed Central ID

PMC8185634

DOI

10.1111/pedi.13134

Scopus ID

2-s2.0-85092736732 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

OBJECTIVE: Patient Reported Outcomes Measurement Information System (PROMIS) includes numerous domains to assess functioning among the pediatric population. These domains, however, have not been evaluated for use in children with type 1 diabetes (T1D). The objective of this study was to determine the measurement properties of PROMIS domains (pain behavior, pain quality, physical stress experience, physical activity, strength impact, and profile-25) in children with T1D.

METHODS: This is a cross-sectional study of children with T1Drecruited from tertiary care facilities. To determine construct validity, we compared PROMIS T-scores between known-groups based on (a) glycemic control, hemoglobin A1c (HbA1c%) and (b) self-reported general health, using t test or analysis of variance. Reliability was determined using Cronbach's alpha and item response theory reliability. We also determined agreement between parent-proxy and child self-report PROMIS scores.

RESULTS: Our study included 192 children, mean age 12.7 (SD = 2.9) years, eligible to self-report PROMIS surveys. There were significant differences in physical stress experience and pain intensity between children with HbA1c < 10% and those with HbA1c ≥ 10%. There also were significant differences in T-scores for all domains except physical function mobility and strength impact among children with poor/fair, good, very good/excellent general health. All valid domains had reliability >0.70. More than 40% of child-parent pairs were in agreement, with intraclass correlations coefficients (ICC) ranging between 0.41 and 0.63 for all domains, except pain behavior (%agreement = 23%; ICC = 0.29).

CONCLUSIONS: Most of the PROMIS domains tested are valid, reliable, and able to differentiate children with T1D who report different general health states. There is moderate agreement between child-parent pairs for all domains except pain behavior.

Author List

Singh A, Dasgupta M, Retherford D, Fiallo-Scharer R, Simpson PM, Panepinto JA

Authors

Rosanna V. Fiallo-Scharer MD Professor in the Pediatrics department at Medical College of Wisconsin
Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
Ashima Singh PhD Assistant Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Exercise
Female
Health Status
Humans
Information Systems
Male
Muscle Strength
Patient Reported Outcome Measures
Reproducibility of Results
Self Report