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Sodium Nitroprusside-Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements. JACC Basic Transl Sci 2020 Feb;5(2):183-192

Date

03/07/2020

Pubmed ID

32140624

Pubmed Central ID

PMC7046538

DOI

10.1016/j.jacbts.2019.11.010

Scopus ID

2-s2.0-85080072630 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Sodium nitroprusside-enhanced cardiopulmonary resuscitation has shown superior resuscitation rates and neurologic outcomes in large animal models supporting the need for a randomized human clinical trial. This study is the first to show nonselective pulmonary vasodilation as a potential mechanism for the hemodynamic benefits. The pulmonary shunting that is created requires increased oxygen treatment, but the overall improvement in blood flow increases minute oxygen delivery to tissues. In this context, hypoxemia is an important safety endpoint and a 100% oxygen ventilation strategy may be necessary for the first human clinical trial.

Author List

Ripeckyj A, Kosmopoulos M, Shekar K, Carlson C, Kalra R, Rees J, Aufderheide TP, Bartos JA, Yannopoulos D

Author

Tom P. Aufderheide MD Professor in the Emergency Medicine department at Medical College of Wisconsin