Faculty Collaboration Database

Cognitive fatigue and cortical-striatal network in old age. Aging (Albany NY) 2019 Apr 17;11(8):2312-2326

Date

04/18/2019

Pubmed ID

30995207

Pubmed Central ID

PMC6519999

DOI

10.18632/aging.101915

Scopus ID

2-s2.0-85065596523 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. We revealed that decreased connectivity strength of the cortical-striatal network over the course of the task was related to higher CF. Correlation between CF and the cortical-striatal network was more robust in anterior relative to posterior components. Moreover, a positive relationship between reliance on the anterior part of the cortical-striatal network and cognitive performance only existed among older adults experiencing low CF. These findings suggest a crucial role of the cortical-striatal network, especially the anterior component, in linking to CF. The PASA phenomenon may only be applicable to older adults without vulnerability to CF.

Author List

Ren P, Anderson AJ, McDermott K, Baran TM, Lin F

Author

Andrew J. Anderson PhD Assistant Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Aging
Cerebral Cortex
Cognition
Corpus Striatum
Female
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Reaction Time