Reproducibility of electrophysiologic testing during antiarrhythmic therapy for ventricular arrhythmias secondary to coronary artery disease. Am J Cardiol 1992 May 15;69(16):1296-9
Date
05/15/1992Pubmed ID
1585863DOI
10.1016/0002-9149(92)91224-rScopus ID
2-s2.0-0026735885 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Although electrophysiologic studies are often used to assess antiarrhythmic drug efficacy in patients with ventricular tachycardia (VT), the reproducibility of these studies during therapy has not been definitively established. Confirmation studies were performed during drug therapy in 64 patients (51 men, mean age 63 years) with sustained ventricular arrhythmias induced during initial study to assess the reproducibility of drug effect. All patients had coronary artery disease. The stimulation protocol used included the serial introduction of up to 3 premature ventricular stimuli during sinus rhythm and with ventricular pacing at 2 pacing rates. Rapid ventricular pacing techniques were also used. Antiarrhythmic drug efficacy was confirmed in 77% of patients. Sustained VT was induced at repeat electrophysiologic study in 19% of patients during antiarrhythmic therapy that was previously thought to be effective. In summary, electrophysiologic study results during antiarrhythmic therapy exhibit significant day-to-day variability. Sustained VT can be induced during antiarrhythmic therapy that was previously defined as effective by programmed stimulation in a substantial number of patients.
Author List
Ferrick KJ, Luce J, Miller S, Mercando AD, Kim SG, Roth JA, Fisher JDAuthor
James A. Roth MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Coronary Disease
Electrophysiology
Female
Humans
Male
Middle Aged
Prospective Studies
Reproducibility of Results
