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Assessing Interocular Symmetry of the Foveal Cone Mosaic. Invest Ophthalmol Vis Sci 2020 Dec 01;61(14):23

Date

12/18/2020

Pubmed ID

33331861

Pubmed Central ID

PMC7746960

DOI

10.1167/iovs.61.14.23

Scopus ID

2-s2.0-85098742066 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

PURPOSE: To test the hypothesis that foveal cone topography is symmetrical between contralateral eyes.

METHODS: We used adaptive optics scanning light ophthalmoscopy to acquire images of the foveal cone mosaic in each eye of 58 subjects with normal vision (35 female, 23 male). Cones were semiautomatically identified over a 300 × 300-µm foveal area. From these cone coordinates, maps of cone density were derived, and we extracted estimates of peak cone density from each map. Mosaic regularity was assessed using Voronoi cell area regularity (VCAR). Average roundness and average area of the 70%, 75%, 80%, 85%, and 90% of peak density isodensity contours were evaluated.

RESULTS: The average peak cone density for right eyes was 180,286 cones/mm2 (n = 49) and for left eyes was 182,397 cones/mm2 (n = 45), with a mean absolute difference of 6363 cones/mm2 (n = 43). Peak density, cone spacing, VCAR, and average area within the isodensity contours of fellow eyes were not significantly different (P = 0.60, P = 0.83, P = 0.30, and P = 0.39, respectively). However, the average roundness of the isodensity contours was 2% more circular in the right eyes than in the left eyes (P = 0.02).

CONCLUSIONS: There is interocular symmetry of peak foveal cone density, mosaic regularity, and area encompassing the most densely packed cells in subjects with normal vision. The origin and significance of the observed interocular difference in average roundness of the isodensity contours are unclear.

Author List

Cava JA, Allphin MT, Mastey RR, Gaffney M, Linderman RE, Cooper RF, Carroll J

Authors

Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Robert F. Cooper Ph.D Assistant Professor in the Biomedical Engineering department at Marquette University




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Cell Count
Child
Female
Fovea Centralis
Humans
Male
Middle Aged
Ophthalmoscopy
Retinal Cone Photoreceptor Cells
Young Adult