Faculty Collaboration Database

Stimulation of the pelvic nerve increases bladder capacity in the PGE₂ cat model of overactive bladder. Am J Physiol Renal Physiol 2020 Jun 01;318(6):F1357-F1368

Date

04/21/2020

Pubmed ID

32308021

Pubmed Central ID

PMC7717121

DOI

10.1152/ajprenal.00068.2020

Scopus ID

2-s2.0-85084695863 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Selective electrical stimulation of the pudendal nerve exhibits promise as a potential therapy for treating overactive bladder (OAB) across species (rats, cats, and humans). More recently, pelvic nerve (PelN) stimulation was demonstrated to improve cystometric bladder capacity in a PGE₂ rat model of OAB. However, PelN stimulation in humans or in an animal model that is more closely related to humans has not been explored. Therefore, our objective was to quantify the effects of PGE₂ and PelN stimulation in the cat. Acute cystometry experiments were conducted in 14 α-chloralose-anesthetized adult, neurologically intact female cats. Intravesical PGE₂ decreased bladder capacity, residual volume, threshold contraction pressure, and mean contraction pressure. PelN stimulation reversed the PGE₂-induced decrease in bladder capacity and increased evoked external urethral sphincter electromyographic activity without influencing voiding efficiency. The increases in bladder capacity generated by PelN stimulation were similar in the rat and cat, but the stimulation parameters to achieve this effect differed (threshold amplitude at 10 Hz in the rat vs. twice threshold amplitude at 1 Hz in the cat). These results highlight the potential of PGE₂ as a model of OAB and provide further evidence that PelN stimulation is a promising approach for the treatment of OAB symptoms.

Author List

Langdale CL, Hokanson JA, Milliken PH, Sridhar A, Grill WM

Author

James A. Hokanson PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cats
Dinoprostone
Disease Models, Animal
Electric Stimulation Therapy
Female
Muscle Contraction
Muscle, Smooth
Pelvis
Pressure
Urinary Bladder
Urinary Bladder, Overactive
Urodynamics