Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression. IEEE Trans Neural Syst Rehabil Eng 2018 Aug;26(8):1636-1644
Date
07/14/2018Pubmed ID
30004881Pubmed Central ID
PMC6531051DOI
10.1109/TNSRE.2018.2854675Scopus ID
2-s2.0-85049801947 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Bladder overactivity and incontinence and dysfunction can be mitigated by electrical stimulation of the pudendal nerve applied at the onset of a bladder contraction. Thus, it is important to predict accurately both bladder pressure and the onset of bladder contractions. We propose a novel method for prediction of bladder pressure using a time-dependent spectrogram representation of external urethral sphincter electromyographic (EUS EMG) activity and a least absolute shrinkage and selection operator regression model. There was a statistically significant improvement in prediction of bladder pressure compared with methods based on the firing rate of EUS EMG activity. This approach enabled prediction of the onset of bladder contractions with 91% specificity and 96% sensitivity and may be suitable for closed-loop control of bladder continence.
Author List
Rutter EM, Langdale CL, Hokanson JA, Hamilton F, Tran H, Grill WM, Flores KBAuthor
James A. Hokanson PhD Assistant Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsAnimals
Computer Simulation
Electromyography
Female
Models, Theoretical
Muscle Contraction
Pudendal Nerve
Rats
Rats, Wistar
Urethra
Urinary Bladder
Urinary Incontinence
