Post-transplant primary cutaneous peripheral T-cell lymphoma not otherwise specified in a pediatric patient. J Cutan Pathol 2021 May;48(5):706-712
Date
01/22/2021Pubmed ID
33476057DOI
10.1111/cup.13967Scopus ID
2-s2.0-85102302501 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Solid organ and hematopoietic stem cell transplantation may be complicated by the development of post-transplant lymphoproliferative disorders (PTLDs). The World Health Organization categorizes PTLDs into four entities including non-destructive, monomorphic, polymorphic, and classical Hodgkin lymphoma types. The most common PTLDs are B-cell lymphomas, with T-cell lymphomas accounting for only a few cases. Cutaneous T-cell lymphomas are rarer still in post-transplant patients with primary cutaneous peripheral T-cell lymphoma being an extraordinarily rare subtype in this population. PTLDs may be aggressive and are often associated with high morbidity and mortality. Advances in medicine have led to increased awareness of PTLDs and improved diagnostic tools which assist in the diagnosis of these conditions. However, the clinical and histopathologic heterogeneity of PTLDs may make diagnosis a challenge. In the transplant patient population, the cutaneous manifestations of the lymphoproliferative disease may mimic other conditions, such as eczematous dermatitis and graft-vs-host disease. Herein, we report a case of post-transplant primary cutaneous peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) in a pediatric heart transplant patient and describe the clinical presentation and diagnostic histopathologic features.
Author List
Cardwell LA, Majerowski J, Chiu YE, Harrington AM, Sokumbi OAuthors
Yvonne E. Chiu MD Vice Chair, Professor in the Dermatology department at Medical College of WisconsinAlexandra M. Harrington MD Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultAutografts
Biopsy
CD3 Complex
Chemoradiotherapy
Child, Preschool
Diagnosis, Differential
Eczema
Female
Graft vs Host Disease
Heart Transplantation
Hematopoietic Stem Cell Transplantation
Humans
Immunohistochemistry
Lymphadenopathy
Lymphoma, T-Cell, Cutaneous
Lymphoma, T-Cell, Peripheral
Lymphoproliferative Disorders
Male
Middle Aged
Neutropenia
Recurrence
Skin
Skin Neoplasms
