Faculty Collaboration Database

Solid organ donor-recipient race-matching: analysis of the United Network for Organ Sharing database. Transpl Int 2021 Apr;34(4):640-647

Date

02/03/2021

Pubmed ID

33527542

DOI

10.1111/tri.13832

Scopus ID

2-s2.0-85101908297 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Donor ethnicity is a prognosticator in organ transplant. However, the impact of donor/recipient race-matching is unclear. We hypothesized that there would be increased survival in donor-recipient race-matched organ recipients because of genetic and physiologic similarities. The UNOS database from 1999 to 2018 was queried for all solid organ transplantations including heart, lung, liver, kidney, and pancreas transplants. Data were sorted by donor and recipient race into matched and unmatched categories for Caucasian, African American, and Hispanic transplant recipients. After controlling for potential confounders via inverse propensity of treatment weighting, post-transplant patient and graft survival were compared between race-matched and -unmatched donor groups for each organ. Race-matched Caucasian recipients experienced 1-3% improvement in mortality across most time points in lung, liver, and pancreas transplants, while Hispanics did not benefit. Matched African American recipients experienced 4-6% improvement in patient and graft survival in liver transplant but had 7-9% worse survival rates at 5 years in lung and pancreas transplants. Race-matching does not influence patient outcomes enough to factor into organ transplant offers. African American liver transplant recipients benefited the most. Matching was detrimental to African American lung and pancreas transplant recipients indicating there may be other factors influencing the outcomes of these transplants.

Author List

LeClaire JM, Smith NJ, Chandratre S, Rein L, Kamalia MA, Kohmoto T, Joyce LD, Joyce DL

Authors

Takushi Kohmoto MD, PhD Professor in the Surgery department at Medical College of Wisconsin
Lisa E. Rein Biostatistician III in the Institute for Health and Equity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Graft Survival
Humans
Liver Transplantation
Pancreas Transplantation
Registries
Survival Rate
Tissue Donors
Tissue and Organ Procurement
United States