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Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. Arch Neurol 1995 Jun;52(6):593-601

Date

06/01/1995

Pubmed ID

7763208

DOI

10.1001/archneur.1995.00540300067015

Scopus ID

2-s2.0-0029054076 (requires institutional sign-in at Scopus site)   320 Citations

Abstract

OBJECTIVE: To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).

DESIGN: Functional neuroimaging using time-series echo-planar MRI.

SETTING: University medical center research facility.

SUBJECTS: Five healthy, right-handed, young adults.

MAIN OUTCOME MEASURES: Number of MRI voxels in left and right hemispheres showing task-related signal increases during two contrasting auditory processing tasks. The nonlinguistic task involved processing of pure tones, while the linguistic task involved processing of single words based on semantic content.

RESULTS: The pure-tone processing task activated temporal lobe auditory areas and dorsolateral frontal regions bilaterally. Using this task as a control condition, the semantic processing task resulted in lateralized activity in distributed regions of the left hemisphere. A significant effect of task on intrahemispheric activity pattern was demonstrated in every subject. Results were reproduced in preliminary studies of test-retest reliability.

CONCLUSIONS: The results demonstrate the lateralized anatomy of semantic linguistic systems in contrast to non-linguistic auditory sensory processors and introduce a task subtraction technique adapted for functional MRI as a noninvasive measure of language lateralization.

Author List

Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Jesmanowicz A, Hyde JS

Author

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Auditory Perception
Brain
Brain Mapping
Cerebrovascular Circulation
Female
Functional Laterality
Humans
Language
Magnetic Resonance Imaging
Male
Psychomotor Performance
Subtraction Technique