AOBase: a database for antisense oligonucleotides selection and design. Nucleic Acids Res 2006 Jan 01;34(Database issue):D664-7
Date
12/31/2005Pubmed ID
16381954Pubmed Central ID
PMC1347428DOI
10.1093/nar/gkj065Scopus ID
2-s2.0-33644877165 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Antisense oligonucleotides (ODNs) technology is one of the important approaches for the sequence-specific knockdown of gene expression. ODNs have been used as research tools in the post-genome era, as well as new types of therapeutic agents. Since finding effective target sites within RNA is a hard work for antisense ODNs design, various experimental methods and computational approaches have been proposed. For better sharing of the experimented and published ODNs, valid and invalid ODNs reported in literatures are screened, collected and stored in AOBase. Till now, approximately 700 ODNs against 46 target mRNAs are contained in AOBase. Entries can be explored via TargetSearch and AOSearch web retrieval interfaces. AOBase can not only be useful in ODNs selection for gene function exploration, but also contribute to mining rules and developing algorithms for rational ODNs design. AOBase is freely accessible via http://www.bioit.org.cn/ao/aobase.
Author List
Bo X, Lou S, Sun D, Yang J, Wang SAuthor
Daochun Sun PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsDatabases, Nucleic Acid
Internet
Oligonucleotides, Antisense
RNA, Messenger
Software
User-Computer Interface
