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Effects of prolonged sleep deprivation on local rates of cerebral energy metabolism in freely moving rats. J Neurosci 1994 Nov;14(11 Pt 2):6769-78

Date

11/01/1994

Pubmed ID

7965078

Pubmed Central ID

PMC6577256

DOI

10.1523/JNEUROSCI.14-11-06769.1994

Scopus ID

2-s2.0-0028006692 (requires institutional sign-in at Scopus site)   72 Citations

Abstract

Although sleep deprivation interferes with biological processes essential for performance, health, and longevity, previous studies have failed to reveal any structural or functional changes in brain. We have therefore measured local rates of cerebral glucose utilization (ICMRglc) with the quantitative autoradiographic 2-14C-deoxyglucose method in an effort to determine if and, if so, where sleep deprivation might affect function in sleep-deprived rats. Sleep deprivation was maintained for 11-12 d, long enough to increase whole body energy metabolism, thus confirming that pathophysiological processes that might involve brain functions were evolving. Deep brain temperature was also measured in similarly treated rats and found to be mildly elevated relative to core body temperature. Despite the increased deep brain temperature, systemic hypermetabolism, and sympathetic activation, ICMRglc was not elevated in any of the 60 brain structures examined. Average glucose utilization in the brain as a whole was unchanged in the sleep-deprived rats, but regional decreases were found. The most marked decreases in ICMRglc were in regions of the hypothalamus, thalamus, and limbic system. Mesencephalic and pontine regions were relatively unaffected except for the central gray area. The medulla was entirely normal. The effects of sleep deprivation on brain tended, therefore, to be unidirectional toward decreased energy metabolism, primarily in regions associated with mechanisms of thermoregulation, endocrine regulation, and sleep. Correspondence was found between the hypometabolic brain regions and some aspects of peripheral symptoms.

Author List

Everson CA, Smith CB, Sokoloff L

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Autoradiography
Body Temperature Regulation
Brain
Energy Metabolism
Glucose
Hydroxybutyrates
Male
Rats
Rats, Sprague-Dawley
Sleep
Sleep Deprivation