Plegia to walking: AHSCBMT in severe NMOSD relapse. BMJ Neurol Open 2020;2(2):e000073
Date
03/09/2021Pubmed ID
33681798Pubmed Central ID
PMC7903183DOI
10.1136/bmjno-2020-000073Scopus ID
2-s2.0-85105891279 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
OBJECTIVES: Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% of patients with optic neuritis attacks have no or a partial recovery.
METHODS: Results from The European Group for Blood and Marrow Transplantation Autoimmune Diseases Working Party imply failure of autologous haematopoietic stem cell bone marrow transplantation.
RESULTS AND CONCLUSION: We present a case that despite eventual relapse, made a remarkable functional recovery after bone marrow transplantation which may justify bone marrow transplantation in severe cases.