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Plegia to walking: AHSCBMT in severe NMOSD relapse. BMJ Neurol Open 2020;2(2):e000073

Date

03/09/2021

Pubmed ID

33681798

Pubmed Central ID

PMC7903183

DOI

10.1136/bmjno-2020-000073

Scopus ID

2-s2.0-85105891279   1 Citation

Abstract

OBJECTIVES: Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% of patients with optic neuritis attacks have no or a partial recovery.

METHODS: Results from The European Group for Blood and Marrow Transplantation Autoimmune Diseases Working Party imply failure of autologous haematopoietic stem cell bone marrow transplantation.

RESULTS AND CONCLUSION: We present a case that despite eventual relapse, made a remarkable functional recovery after bone marrow transplantation which may justify bone marrow transplantation in severe cases.

Author List

Carlisle N, Hari P, Brod S

Author

Staley A. Brod MD Professor in the Neurology department at Medical College of Wisconsin