Faculty Collaboration Database

Physiology and pathophysiology of cortico-basal ganglia-thalamocortical loops: theoretical and practical aspects. Prog Neuropsychopharmacol Biol Psychiatry 2002 May;26(4):771-804

Date

08/22/2002

Pubmed ID

12188109

DOI

10.1016/s0278-5846(02)00201-4

Scopus ID

2-s2.0-0036016296 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

A new theoretical framework is used to analyze functions and pathophysiological processes of cortico-basal ganglia-thalamocortical loops and to demonstrate the hierarchical relationships between various loops. All hierarchical levels are built according to the same functional principle: Each loop is a neural optimal control system (NOCS) and includes a model of object behavior and an error distribution system. The latter includes dopaminergic neurons and is necessary to tune the model to a controlled object (CO). The regularities of pathophysiological processes in NOCSs are analyzed. Mechanisms of current functional neurosurgical procedures like lesioning and deep brain stimulation (DBS) of various basal ganglia structures and neurotransplantation are described based on proposed theoretical ideas. Parkinson's disease (PD) is used to exemplify clinical applications of the proposed theory. Within the proposed theoretical framework, PD must be considered as a disease of the error distribution system. The proposed theoretical views have broad fundamental and clinical applications.

Author List

Baev KV, Greene KA, Marciano FF, Samanta JE, Shetter AG, Smith KA, Stacy MA, Spetzler RF

Author

Karl A. Greene MD Adjunct Assistant Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Basal Ganglia
Behavior
Cerebral Cortex
Humans
Nerve Net
Neural Pathways
Thalamus