Case Series: Development of Polyps as a Late Effect After Total Body Irradiation-based Hematopoietic Cell Transplantation in Children With High-risk Leukemia. J Pediatr Hematol Oncol 2021 Nov 01;43(8):e1159-e1163
Date
04/09/2021Pubmed ID
33828034Pubmed Central ID
PMC8492786DOI
10.1097/MPH.0000000000002152Scopus ID
2-s2.0-85120523873 (requires institutional sign-in at Scopus site)Abstract
Advancements in hematopoietic cell transplantation (HCT) have led to increased survivorship rates in many childhood diseases. However, this growing group of long-term survivors face a myriad of late effects. There are currently limited guidelines for surveillance of gastrointestinal polyps for pediatric transplant patients. Here we describe 5 patients undergoing HCT with total body irradiation-based conditioning regimens for leukemia who developed symptomatic polyps a median of 4.5 (range: 0.75 to 5.75) years after HCT. Because of limited surveillance guidelines in children, we conclude that the development of new or progressive symptoms related to the gastrointestinal tract deserves prompt recognition and evaluation.
Author List
Knight B, Anderson L, Lerner D, Phelan R, Thakar MSAuthors
Lynnette J. Anderson NP Manager NP/PA in the Pediatrics department at Medical College of WisconsinDiana Lerner MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Rachel A. Phelan MD, MPH Associate Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAge of Onset
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
Humans
Infant
Leukemia
Male
Polyps
Prognosis
Retrospective Studies
Transplantation Conditioning
Whole-Body Irradiation
