Faculty Collaboration Database

Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease. Crit Care Med 2021 Jul 01;49(7):1095-1106

Date

03/18/2021

Pubmed ID

33729719

DOI

10.1097/CCM.0000000000004921

Scopus ID

2-s2.0-85108386465 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.

DESIGN: Secondary analysis of three prospective, observational, multicenter studies.

SETTING: Cohort studies conducted in 2004, 2010, and 2016.

PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma.

CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease.

Author List

Tejerina EE, Pelosi P, Robba C, Peñuelas O, Muriel A, Barrios D, Frutos-Vivar F, Raymondos K, Du B, Thille AW, Ríos F, González M, Del-Sorbo L, Marín MDC, Valle Pinheiro B, Soares MA, Nin N, Maggiore SM, Bersten A, Amin P, Cakar N, Young Suh G, Abroug F, Jibaja M, Matamis D, Ali Zeggwagh A, Sutherasan Y, Anzueto A, Esteban A, VENTILA Group

Author

Rahul Sudhir Nanchal MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Brain Injuries, Traumatic
Female
Hospital Mortality
Humans
Intensive Care Units
Length of Stay
Male
Middle Aged
Multicenter Studies as Topic
Nervous System Diseases
Noninvasive Ventilation
Observational Studies as Topic
Prospective Studies
Respiration, Artificial
Risk Factors
Simplified Acute Physiology Score
Tracheotomy
Ventilator Weaning