Survival benefit of renal transplantation in octogenarians. Clin Transplant 2020 Nov;34(11):e14074
Date
09/04/2020Pubmed ID
32882090DOI
10.1111/ctr.14074Scopus ID
2-s2.0-85091505848 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
BACKGROUND: Elderly patients are the fastest growing population requiring renal replacement therapy. As previous studies have shown a survival benefit of kidney transplantation compared to dialysis for end-stage renal disease, we sought to evaluate if this survival benefit extends to octogenarians.
METHODS: This was a single-center retrospective cohort study of renal allograft recipients ≥80 years transplanted from 1999 to 2014 who were compared to patients listed during the same period that did not proceed to transplantation. A secondary matched group was selected from the UNOS transplant waitlist database. The primary outcome was patient survival. Secondary outcomes included graft survival and rejection incidence.
RESULTS: Thirty-three transplanted patients were compared to 71 patients waitlisted at our center and 66 patients from the UNOS database. Patients in the study group were transplanted 20.8 ± 16.1 months after listing. Patient survival was 87.8% at 6 months and 1 year and 71.4% at 3 years. Kidney transplantation was associated with a significant decrease in the risk of death after listing (HR: 0.22, CI: 0.11-0.45, P < .001).
CONCLUSION: With escalating life expectancy, kidney transplantation is a suitable treatment option in eligible octogenarians.
Author List
Ravichandran BR, Sparkes TM, Masters BM, Thomas B, Demehin M, Bromberg JS, Haririan AAuthor
Beje Thomas MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Graft Rejection
Graft Survival
Humans
Kidney Failure, Chronic
Kidney Transplantation
Renal Dialysis
Retrospective Studies
Survival Rate
