Medical College of Wisconsin
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Eye organogenesis: A hierarchical view of ocular development. Curr Top Dev Biol 2019;132:351-393

Date

02/25/2019

Pubmed ID

30797514

DOI

10.1016/bs.ctdb.2018.12.008

Scopus ID

2-s2.0-85059358001 (requires institutional sign-in at Scopus site)   79 Citations

Abstract

This chapter provides an overview of the early developmental origins of six ocular tissues: the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of these tissue types are concurrently specified and undergo a complex set of morphogenetic movements that facilitate their structural interconnection. Within the context of vertebrate eye organogenesis, we also discuss the genetic hierarchies of transcription factors and signaling pathways that regulate growth, patterning, cell type specification and differentiation.

Author List

Miesfeld JB, Brown NL

Author

Joel Bryan Miesfeld PhD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Ciliary Body
Cornea
Eye
Gene Expression Regulation, Developmental
Humans
Lens, Crystalline
Organogenesis
Retina
Transcription Factors