Comparative Outcomes of Patients With Advanced Renal Dysfunction Undergoing Transcatheter Aortic Valve Replacement in the United States From 2011 to 2014. Circ Cardiovasc Interv 2017 Oct;10(10)
Date
09/28/2017Pubmed ID
28951396DOI
10.1161/CIRCINTERVENTIONS.117.005477Scopus ID
2-s2.0-85040777100 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
BACKGROUND: Renal dysfunction is intricately linked to aortic stenosis, with over 25% patients presenting for transcatheter aortic valve replacement having chronic kidney disease (CKD). Prevalence and outcomes of patients with CKD, especially those with end-stage renal disease (ESRD), are controversial. We aimed to compare in-hospital outcomes of patients with CKD or ESRD with those patients with no CKD/ESRD.
METHODS AND RESULTS: Data were obtained using the national inpatient sample between the years 2011 and 2014. We used the International Classification of Diseases, Ninth Edition, Clinical Modification procedure codes 350.5 and 350.6 to identify patients undergoing transcatheter aortic valve replacement. Primary outcome of interest was in-hospital mortality. A 2-tailed P value <0.01 was considered to denote statistical significance for all analyses. We identified 42 189 patients who underwent transcatheter aortic valve replacement between the years 2011 and 2014. Of these, 62.1% (n=26 229) had no CKD/ESRD, 33.7% (n=14 252) had CKD, and 4% (n=1708) had ESRD. Patients with CKD or ESRD had greater in-hospital mortality, hospital length of stay, hemorrhage requiring transfusion, and permanent pacemaker implantation (P<0.001).
CONCLUSIONS: Patients with CKD and ESRD have increased in-hospital mortality and periprocedural adverse events with longer hospital length of stay, when compared with those without CKD.
Author List
Mohananey D, Griffin BP, Svensson LG, Popovic ZB, Tuzcu EM, Rodriguez LL, Kapadia SR, Desai MYAuthor
Divyanshu Mohananey MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Aortic Valve Stenosis
Female
Humans
Male
Renal Insufficiency, Chronic
Retrospective Studies
Transcatheter Aortic Valve Replacement
United States
