Hippocampal Volumes in Amnestic and Non-Amnestic Mild Cognitive Impairment Types Using Two Common Methods of MCI Classification. J Int Neuropsychol Soc 2022 Apr;28(4):391-400
Date
06/17/2021Pubmed ID
34130767DOI
10.1017/S1355617721000564Scopus ID
2-s2.0-85108188515 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
OBJECTIVES: Mild cognitive impairment (MCI) types may have distinct neuropathological substrates with hippocampal atrophy particularly common in amnestic MCI (aMCI). However, depending on the MCI classification criteria applied to the sample (e.g., number of abnormal test scores considered or thresholds for impairment), volumetric findings between MCI types may change. Additionally, despite increased clinical use, no prior research has examined volumetric differences in MCI types using the automated volumetric software, Neuroreader™.
METHODS: The present study separately applied the Petersen/Winblad and Jak/Bondi MCI criteria to a clinical sample of older adults (N = 82) who underwent neuropsychological testing and brain MRI. Volumetric data were analyzed using Neuroreader™ and hippocampal volumes were compared between aMCI and non-amnestic MCI (naMCI).
RESULTS: T-tests revealed that regardless of MCI classification criteria, hippocampal volume z-scores were significantly lower in aMCI compared to naMCI (p's < .05), and hippocampal volume z-scores significantly differed from 0 (Neuroreader™ normative mean) in the aMCI group only (p's < .05). Additionally, significant, positive correlations were found between measures of delayed recall and hippocampal z-scores in aMCI using either MCI classification criteria (p's < .05).
CONCLUSIONS: We provide evidence of correlated neuroanatomical changes associated with memory performance for two commonly used neuropsychological MCI classification criteria. Future research should investigate the clinical utility of hippocampal volumes analyzed via Neuroreader™ in MCI.
Author List
Emmert NA, Reiter KE, Butts A, Janecek JK, Agarwal M, Franczak M, Reuss J, Klein A, Wang Y, Umfleet LGAuthors
Mohit Agarwal MD Associate Professor in the Radiology department at Medical College of WisconsinAlissa Butts PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin
Julie K. Janecek PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Andrew P. Klein MD Chief, Associate Professor in the Radiology department at Medical College of Wisconsin
Laura Umfleet PsyD Associate Professor in the Neurology department at Medical College of Wisconsin
Yang Wang MD Professor in the Radiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AgedAmnesia
Cognitive Dysfunction
Hippocampus
Humans
Neuroimaging
Neuropsychological Tests
