Faculty Collaboration Database

Transplant of a Kidney from a Hepatitis C Viremic Donor to a Naïve Recipient without Viral Transmission: A Case Report. Am J Case Rep 2021 May 06;22:e927532

Date

05/07/2021

Pubmed ID

33953151

Pubmed Central ID

PMC8112284

DOI

10.12659/AJCR.927532

Scopus ID

2-s2.0-85105227242 (requires institutional sign-in at Scopus site)

Abstract

BACKGROUND Kidneys from deceased donors who were positive for hepatitis C virus (HCV) on a nucleic acid amplification test (NAT) are not given to anti-HCV antibody-negative recipients. This is because of the high risk of HCV transmission, combined with the lack of effective antiviral treatment. Several studies have demonstrated rates of transmission of HCV from anti-HCV-positive/HCV NAT-positive donors to anti-HCV-negative recipients of 100%. Ours is the first report of transplantation of a kidney from an anti-HCV antibody-positive/HCV NAT-positive donor into an anti-HCV antibody-negative recipient who remains anti-HCV antibody-negative at 3 months after transplant with no treatment. CASE REPORT A 49-year-old man had a history of end-stage renal disease that was presumed to be secondary to type ll diabetes. He received a kidney from a deceased donor who was HCV antibody-positive/NAT-negative. The patient's HCV antibody status was checked prior to transplant and he was found to be negative and nonreactive. Since the transplant, his HCV viral load has been checked 5 times, on postoperative days 15, 23, 44, 62, and 64; each time, it has been undetectable. Furthermore, the patient's HCV antibody status was rechecked 1 month after transplant and it remained negative and nonreactive. CONCLUSIONS Further research is required on the accuracy of polymerase chain reaction as an indicator of donor HCV infection when the quantity of the viral load is not reported.

Author List

Rawashdeh B, Hulse J, Agarwal A

Author

Badi Rawashdeh MBBS Instructor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Hepacivirus
Hepatitis C
Hepatitis C Antibodies
Humans
Kidney
Male
Middle Aged
Tissue Donors