Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy. Epilepsy Behav 2012 Aug;24(4):399-402
Date
07/04/2012Pubmed ID
22749239Pubmed Central ID
PMC3408819DOI
10.1016/j.yebeh.2012.05.018Scopus ID
2-s2.0-84864296914 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Although antiepileptic drugs are often effective in the control of seizures, some patients show little or no improvement. As alternative treatments, different dietary modifications were shown to be beneficial for patients with poor tolerance for AEDS. Previous reports have shown that rice-based oral electrolyte hydration therapy is effective in seizure control in patients with refractory absence seizures. In the present study, using an animal model of absence epilepsy, we showed that the occurrence of spike-and-wave discharges significantly decreases upon switching to electrolyte therapy. We also showed that consumption of solution with the same osmolarity as rice-based oral electrolyte solution leads to a decrease in the number of spike-and-wave discharges per hour. We suggest that the antiepileptic effect of rice-based oral electrolyte hydration therapy can be at least in part due to hyperosmolarity of the ingested solution.
Author List
Talnov AN, Isaeva E, Savotchenko AV, Dovgalets GV, Ochoa JG, Holmes GL, Isaev DAuthor
Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Analysis of VarianceAnimals
Anticonvulsants
Brain Waves
Disease Models, Animal
Electroencephalography
Electrolytes
Epilepsy, Absence
Male
Rats
Rats, Mutant Strains
Rats, Wistar
