Effects of isoflurane on hippocampal seizures at immature rats in vivo. Fiziol Zh (1994) 2008;54(5):40-5
Date
12/09/2008Pubmed ID
19058511Scopus ID
2-s2.0-58149335394 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
In the present study we examined the effect of isoflurane on seizure-like activity at hippocampal CA3 pyramidal region of immature rats in vivo. We found that isoflurane in clinically relevant concentrations effectively stops hippocampal seizures. When animal was under isoflurane anesthesia seizure-like activity still can be evoked by application of proconvulstant agents, but this activity was qualitatively different from that obtained in nonanesthetized rats. This observation suggests that the mechanism by which seizures are terminated differ from the mechanism responsible for preventing of the initiation of seizures.
Author List
Isaeva EVAuthor
Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnesthesia, Inhalation
Anesthetics, Inhalation
Animals
Anticonvulsants
Disease Models, Animal
Electroencephalography
Electrophysiology
Hippocampus
Isoflurane
Pyramidal Cells
Rats
Rats, Sprague-Dawley
Seizures
