Faculty Collaboration Database

A comparison of the recovery profiles of desflurane and isoflurane anesthesia in patients undergoing elective supratentorial craniotomy: A randomized controlled trial. Neurol India 2017;65(5):1053-1058

Date

09/08/2017

Pubmed ID

28879896

DOI

10.4103/neuroindia.NI_1136_15

Scopus ID

2-s2.0-85029002000 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

CONTEXT: Few studies have compared recovery profiles of desflurane and isoflurane for patients undergoing elective supratentorial craniotomy. It is not known if the choice of inhalational agent can affect the duration of transient postoperative neurological deficits in these patients.

AIMS: To compare the effect of desflurane and isoflurane on time-to-emergence and time-to-recovery of transient postoperative neurological deficits in patients undergoing supratentorial craniotomy.

SETTINGS AND DESIGN: Prospective, double-blinded, randomized controlled trial at a tertiary care hospital.

METHODS AND MATERIALS: We randomly assigned 60 patients to receive either desflurane or isoflurane during elective supratentorial craniotomy for intra-axial mass lesions. Time-to-emergence and time-to-recovery of transient postoperative neurological deficits were recorded and compared.

STATISTICAL ANALYSIS USED: Parametric variables were compared by the Student's t test. Baseline data was compared using Pearson's chi square test, Fisher's exact test and two proportion Z test.

RESULTS: There was a 35.7%, 31.4% and 34.5% reduction in median times to eye opening, obeying commands and orientation in the desflurane group (n=27) as compared to the isoflurane group (n=28). Five patients were enrolled but not included for analysis-Twelve patients sustained transient neurological deficits after surgery (desflurane, n=3; isoflurane, n=9). No significant difference in the time-to-recovery of transient postoperative neurological deficits was observed.

CONCLUSIONS: Desflurane significantly reduced emergence times, and was able to facilitate an early neurological examination for patients. Additional studies are required to establish the impact of inhalational agents on transient postoperative neurological deficits.

Author List

Paul AP, Vedantam A, Korula G, Chacko AG

Author

Aditya Vedantam MD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anesthetics, Inhalation
Craniotomy
Double-Blind Method
Elective Surgical Procedures
Female
Glioma
Humans
Isoflurane
Male
Postoperative Period
Supratentorial Neoplasms
Wakefulness