Pilot trial to compare tolerance of chlorhexidine gluconate to povidone-iodine antisepsis for central venous catheter placement in neonates. J Perinatol 2009 Dec;29(12):808-13
Date
10/09/2009Pubmed ID
19812587DOI
10.1038/jp.2009.161Scopus ID
2-s2.0-77649241857 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
OBJECTIVE: The purpose of this pilot trial was to determine whether rates of contact dermatitis following cutaneous antisepsis for central catheter placement were similar among neonates treated with chlorhexidine gluconate and povidone-iodine. Chlorhexidine gluconate absorption was also evaluated.
STUDY DESIGN: Infants weighing > or =1500 g and > or =7 days of age were randomized to a 10% povidone-iodine or 2% chlorhexidine gluconate site scrub before catheter placement. Primary outcomes evaluated included dermatitis, catheter colonization and chlorhexidine gluconate absorption.
RESULT: A total of 48 neonates were enrolled. Colonization rates were similar among treatment groups (P<0.6). Dermatitis did not occur at chlorhexidine gluconate (central catheters, n=24; peripheral catheters, n=29) sites. Seven neonates had measurable chlorhexidine gluconate concentrations (range 13 to 100 ng ml(-1)) during catheterization.
CONCLUSION: In this small trial chlorhexidine gluconate antisepsis was tolerated by study neonates. Chlorhexidine gluconate was cutaneously absorbed. Larger trials are needed to determine efficacy and tolerance of chlorhexidine gluconate in neonates.
Author List
Garland JS, Alex CP, Uhing MR, Peterside IE, Rentz A, Harris MCAuthor
Michael R. Uhing MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Infective Agents, LocalCatheterization, Central Venous
Catheters, Indwelling
Chlorhexidine
Dermatitis, Contact
Female
Humans
Infant
Infant, Newborn
Intensive Care Units, Neonatal
Male
Pilot Projects
Povidone-Iodine
Skin Absorption
