Faculty Collaboration Database

Ventilatory response to carbon dioxide in term infants after halothane and nitrous oxide anesthesia. Anesth Analg 1993 Jun;76(6):1234-7

Date

06/01/1993

Pubmed ID

8498659

DOI

10.1213/00000539-199306000-00009

Scopus ID

2-s2.0-0027284850 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

The purpose of this study was to determine whether the ventilatory response to CO2 is depressed in term infants after halothane and N2O anesthesia. Ventilatory response to CO2 was determined by using a maskless CO2 response test in which a ventilation ratio is calculated from measurements of transcutaneous PCO2 (PtcCO2). Ventilation ratio represents the fractional increase in ventilation that occurs in response to inspired CO2. Eight infants were studied who were at least 36 wk gestational age and 12 +/- 4 wk postnatal age, did not have apnea in the perioperative period (values are means +/- SD). Ventilation ratio measured with a 4%-inspired-CO2 stimulus increased significantly after anesthesia (3.5 +/- 0.8 vs 3.0 +/- 0.5, P = 0.02). Baseline PtcCO2 was significantly lower after anesthesia than before anesthesia (37 +/- 4 vs 42 +/- 3, P < 0.01) which may reflect the development of a relative metabolic acidosis. (The occurrence of postoperative metabolic acidosis was in fact documented in another group of eight infants.) Ventilatory response to CO2 was not depressed after halothane and nitrous oxide anesthesia in these term and near-term infants.

Author List

Palmisano BW, Setlock MA, Doyle MK, Rosner DR, Hoffman GM, Eckert JE

Author

George M. Hoffman MD Chief, Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthesia, Inhalation
Carbon Dioxide
Female
Halothane
Humans
Infant
Male
Nitrous Oxide
Respiration
Surgical Procedures, Operative