Faculty Collaboration Database

Cancer among first-degree relatives of probands with invasive and borderline ovarian cancer. Obstet Gynecol 1998 Oct;92(4 Pt 1):589-95

Date

10/09/1998

Pubmed ID

9764634

DOI

10.1016/s0029-7844(98)00275-0

Scopus ID

2-s2.0-0031682074 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

OBJECTIVE: The familial clustering of ovarian, breast, endometrial, colon; and prostate cancer was compared in first-degree relatives of probands with invasive and borderline ovarian cancer to determine coaggregation.

METHODS: Probands (n=392), who had been patients in the Division of Gynecologic Oncology at Washington University, were ascertained consecutively. Family history on 2192 first-degree relatives was collected by personal interviews of the probands and other family members. Estimates of prevalence of cancers in first-degree relatives of the two proband groups were compared. Survival analysis was used to examine the age-at-onset distribution of each cancer in relatives of invasive probands versus relatives of borderline probands.

RESULTS: Among the relatives were 24 cases of ovarian cancer, 46 cases of breast cancer, 13 cases of endometrial cancer, and 25 and 28 cases of colon and prostate cancer, respectively. There were no significant differences in the prevalence of any of these cancers in relatives of the invasive and borderline probands. Cumulative lifetime risk estimates did not differ between the relatives of the two groups for any cancers. Age-at-onset of ovarian cancer did not differ between probands with positive family histories of the five cancers and those with negative histories. The inability to reject the null hypothesis of no differences in the first-degree relatives of our two study groups might be from insufficient power to detect small differences, given our sample size.

CONCLUSION: These results suggest that relatives of patients with invasive and borderline ovarian cancer might share similar cancer risks and age-at-onset distributions.

Author List

Rader JS, Neuman RJ, Brady J, Babb S, Temple S, Kost E, Mutch DG, Herzog TJ

Author

Janet Sue Rader MD Chair, Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Age of Onset
Breast Neoplasms
Colonic Neoplasms
Endometrial Neoplasms
Female
Humans
Male
Middle Aged
Neoplasm Invasiveness
Ovarian Neoplasms
Prostatic Neoplasms