Faculty Collaboration Database

Predicting arterial stiffness with ambulatory blood pressure: an 11-year follow-up. Clin Physiol Funct Imaging 2008 Nov;28(6):378-83

Date

06/11/2008

Pubmed ID

18540874

DOI

10.1111/j.1475-097X.2008.00817.x

Scopus ID

2-s2.0-54249140976 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

No prospective data have been published on whether ambulatory blood pressure (BP) works better than casual measurements in predicting arterial stiffness. This study with 11-year follow-up was launched to evaluate the usefulness of ambulatory intra-arterial BP in predicting pulse wave velocity (PWV). Ninety-seven previously healthy men were recruited from a routine physical check-up at baseline. BP was measured with standard cuff and intra-arterial ambulatory methods. Sixty-seven subjects with no antihypertensive medication were enrolled for a visit after a follow-up of 11 years. Arterial stiffness was estimated with PWV derived with impedance cardiography. Ambulatory 24-h systolic blood pressure (SBP) (r = 0.30, P = 0.01), 24-h mean arterial pressure (r = 0.27, P = 0.03), 24-h pulse pressure (r = 0.27, P = 0.03) and daytime SBP (r = 0.26, P = 0.03) were the best BP variables in predicting future PWV. Casual BP values did not bear significant correlations with future PWV. In hierarchical regression analysis, the best predictive value for future PWV was achieved with the model including ambulatory 24-h SBP, smoking (number of cigarettes) and age (adjusted R(2) = 0.26). In conclusion, to our knowledge, this is the only prospective follow-up study to show that ambulatory BP is superior to casual BP measurement in predicting future PWV.

Author List

Virtanen MP, Kööbi T, Turjanmaa VM, Majahalme S, Tuomisto MT, Nieminen T, Kähönen M

Author

Silja Majahalme MD, PhD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aorta, Thoracic
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases
Elasticity
Follow-Up Studies
Humans
Male
Middle Aged
Plethysmography, Impedance
Popliteal Artery
Predictive Value of Tests
Prospective Studies
Risk Factors
Smoking
Time Factors
Ultrasonography