Faculty Collaboration Database

Metabolic syndrome and arterial stiffness: the Health 2000 Survey. Metabolism 2007 Mar;56(3):320-6

Date

02/13/2007

Pubmed ID

17292719

DOI

10.1016/j.metabol.2006.10.008

Scopus ID

2-s2.0-33846798216 (requires institutional sign-in at Scopus site)   54 Citations

Abstract

Metabolic syndrome and its components have been associated with arterial stiffness and cardiovascular disease. The objective of this study was to examine the independent influences of metabolic syndrome, its components, and other cardiovascular risk factors on arterial stiffness as well as to compare 2 definitions for metabolic syndrome (National Cholesterol Education Program [NCEP] and International Diabetes Federation [IDF]) in their ability to identify subjects with arterial stiffness. The study population consisted of 401 Finnish men and women aged 45 years and older who participated in a substudy of the Finnish population-based Health 2000 Survey. Pulse wave velocity (PWV) measured by whole-body impedance cardiography was used as a marker of elevated arterial stiffness. In multivariate models, systolic blood pressure, age, waist circumference, and fasting blood glucose (P < or = .001 for all) were independent determinants for PWV. In the models including metabolic syndrome instead of its components, the NCEP and IDF definitions were similarly associated with PWV (P < or = .01 for both), the other independent determinants being age, sex (P < .001 for both) and plasma C-reactive protein concentration (P = .016 and P = .005 in models containing the NCEP and IDF definitions, respectively). Systolic blood pressure, age, waist circumference, and fasting blood glucose level were independently associated with increased arterial stiffness. Metabolic syndrome determined increased arterial stiffness independently of other known cardiovascular risk factors. The NCEP and IDF definitions did not differ in their ability to identify subjects with increased arterial stiffness.

Author List

Sipilä K, Koivistoinen T, Moilanen L, Nieminen T, Reunanen A, Jula A, Salomaa V, Kaaja R, Kööbi T, Kukkonen-Harjula K, Majahalme S, Kähönen M

Author

Silja Majahalme MD, PhD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Arteries
Blood Flow Velocity
C-Reactive Protein
Cardiography, Impedance
Cholesterol, LDL
Female
Humans
Male
Metabolic Syndrome
Middle Aged
Pulsatile Flow