Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. Prostaglandins Leukot Essent Fatty Acids 1992 Jul;46(3):215-7

Date

07/11/1992

Pubmed ID

1508954

DOI

10.1016/0952-3278(92)90073-r

Abstract

The plasma cholesterol, plasma malonaldehyde (MDA), platelet thromboxane A2 (TXA2) and vascular prostacyclin (PGI2) were measured in male Sprague-Dawley rats fed diets supplemented with cholesterol (1%) and cholic acid (0.5%). For comparisons, measurements were made in rats fed normal diets. The concentration of cholesterol in the plasma of rats had reached a maximum in 1 week of feeding experimental diets. TXA2 production from collagen and thrombin stimulated platelets was significantly decreased in animals fed experimental diets for 1 week. The production of MDA in the plasma of animals fed experimental diets for 8 weeks was significantly lower compared to the animals fed normal diets. There was a small but significant reduction in the formation of PGI2 in rats fed experimental diets for 8 weeks. These data suggest that feeding cholesterol rich diets to rats alters the platelet membrane properties differently from human and rabbit. Furthermore, cholesterol feeding to rats had some damaging effect on the arterial PGI2 synthesis.

Author List

Arnold JH, Pritchard KA Jr, Greco NJ, Panganamala RV

Author

Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

6-Ketoprostaglandin F1 alpha
Animals
Blood Platelets
Collagen
Epoprostenol
Hypercholesterolemia
Lipid Peroxidation
Male
Platelet Activation
Rats
Rats, Inbred Strains
Thrombin
Thromboxane A2
Thromboxane B2
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a