Stage I and II Hodgkin's disease in the pediatric population. Long-term follow-up of patients staged predominantly clinically. Am J Clin Oncol 1996 Apr;19(2):174-8
Date
04/01/1996Pubmed ID
8610644DOI
10.1097/00000421-199604000-00017Scopus ID
2-s2.0-0029986772 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Between January 1, 1970, and December 31, 1990, 42 consecutive pediatric patients were treated at the Medical College of Wisconsin Affiliated Hospitals for early-stage Hodgkin's disease. Thirty patients were clinically staged. Twelve underwent staging laparotomy as a part of staging work-up. Thirty-one patients were treated with radiation therapy (RT) alone. Eleven were treated with combined chemotherapy and RT. For the entire group, overall survival at 5, 10, and 15 years was 98, 98, and 92%, respectively. Disease-free survival was 86, 86, and 79, respectively. There was no significant difference in overall survival or disease-free survival comparing clinically versus pathologically staged patients. There was a trend toward improved disease-free survival favoring pathologically staged patients; however, this difference did not reach statistical significance (p = 0.07). The long-term results of this series fail to show statistically significant superior disease-free or overall survival with surgical staging.
Author List
Rock DB, Murray KJ, Schultz CJ, Lauer SJ, Wilson JFAuthor
Christopher J. Schultz MD Chair, Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAntineoplastic Combined Chemotherapy Protocols
Biopsy
Bone Marrow
Child
Cohort Studies
Combined Modality Therapy
Disease-Free Survival
Female
Follow-Up Studies
Gallium Radioisotopes
Hodgkin Disease
Humans
Laparotomy
Male
Neoplasm Recurrence, Local
Neoplasm Staging
Neoplasms, Second Primary
Radiotherapy Dosage
Radiotherapy, High-Energy
Retrospective Studies
Survival Rate
Tomography, X-Ray Computed
