Biological resurfacing in a canine model of hip osteoarthritis. Sci Adv 2021 Sep 17;7(38):eabi5918
Date
09/16/2021Pubmed ID
34524840Pubmed Central ID
PMC8443182DOI
10.1126/sciadv.abi5918Scopus ID
2-s2.0-85115146665 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Articular cartilage has unique load-bearing properties but has minimal capacity for intrinsic repair. Here, we used three-dimensional weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model. This resorbable implant was specifically designed to function mechanically from the time of repair and to biologically integrate with native tissues for long-term restoration. A massive osteochondral lesion was created in the hip of skeletally mature hounds and repaired with the implant or left empty (control). Longitudinal outcome measures over 6 months demonstrated that the implant dogs returned to normal preoperative values of pain and function. Anatomical structure and functional biomechanical properties were also restored in the implanted dogs. Control animals never returned to normal and exhibited structurally deficient repair. This study provides clinically relevant evidence that the bicomponent implant may be a potential therapy for moderate hip osteoarthritis.
