Early implementation of stereoelectroencephalography in children: a multiinstitutional case series. J Neurosurg Pediatr 2021 Sep 03;28(6):669-676
Date
09/04/2021Pubmed ID
34479204DOI
10.3171/2021.5.PEDS20923Scopus ID
2-s2.0-85126917462 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
OBJECTIVE: Pediatric stereoelectroencephalography (SEEG) has been increasingly performed in the United States, with published literature being limited primarily to large single-center case series. The purpose of this study was to evaluate the experience of pediatric epilepsy centers, where the technique has been adopted in the last several years, via a multicenter case series studying patient demographics, outcomes, and complications.
METHODS: A retrospective cohort methodology was used based on the STROBE criteria. ANOVA was used to evaluate for significant differences between the means of continuous variables among centers. Dichotomous outcomes were assessed between centers using a univariate and multivariate logistic regression.
RESULTS: A total of 170 SEEG insertion procedures were included in the study from 6 different level 4 pediatric epilepsy centers. The mean patient age at time of SEEG insertion was 12.3 ± 4.7 years. There was no significant difference between the mean age at the time of SEEG insertion between centers (p = 0.3). The mean number of SEEG trajectories per patient was 11.3 ± 3.6, with significant variation between centers (p < 0.001). Epileptogenic loci were identified in 84.7% of cases (144/170). Patients in 140 cases (140/170, 82.4%) underwent a follow-up surgical intervention, with 47.1% (66/140) being seizure free at a mean follow-up of 30.6 months. An overall postoperative hemorrhage rate of 5.3% (9/170) was noted, with patients in 4 of these cases (4/170, 2.4%) experiencing a symptomatic hemorrhage and patients in 3 of these cases (3/170, 1.8%) requiring operative evacuation of the hemorrhage. There were no mortalities or long-term complications.
CONCLUSIONS: As the first multicenter case series in pediatric SEEG, this study has aided in establishing normative practice patterns in the application of a novel surgical technique, provided a framework for anticipated outcomes that is generalizable and useful for patient selection, and allowed for discussion of what is an acceptable complication rate relative to the experiences of multiple institutions.
Author List
Lepard JR, Kim I, Arynchyna A, Lew SM, Bollo RJ, O'Neill BR, Perry MS, Donahue D, Smyth MD, Blount JAuthors
Irene Kim MD Assistant Professor in the Neurosurgery department at Medical College of WisconsinSean Lew MD Chief, Professor in the Neurosurgery department at Medical College of Wisconsin
