Faculty Collaboration Database

Serum insulin-like growth factor-I and serum testosterone status of elderly men in an inpatient rehabilitation unit. Am J Med Sci 1996 Apr;311(4):169-73

Date

04/01/1996

Pubmed ID

8602645

DOI

10.1097/00000441-199604000-00003

Scopus ID

2-s2.0-0029985907 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

This study was designed to estimate the prevalence of hyposomatomedinemia and hypogonadism in an inpatient rehabilitation unit. The authors studied healthy young men (HOM) ages 20-29 years (n=33); healthy old men (HOM) ages 59-98 years (n=27), and elderly men in an inpatient rehabilitation unit (ERM) ages 58-95 years (n=42). Serum concentrations of insulin-like growth factor (IGF-I), total testosterone (TT), and free testosterone (FT) were measured. A low IGF-I level (below the lower 2.5 percentile of HYM) occurred in 85% of the HOM and in 62.5% of the ERM. When a low IGF-I was defined as a value below the 2.5 percentile of the HOM, the prevalence in ERM was 6.2%. A low TT level (below the lower 2.5 percentile of the HOM) occurred in 78% of the HOM and in 90% of the ERM. Low TT, defined as a value below the lower 2.5 percentile of the HOM, occurred in 22% of the ERM. The results with FT were similar. In neither HOM nor ERM was IGF-I significantly correlated to TT and FT. A large percentage of HOM and ERM have severe hypogonadism (TT<193 ng/mL) as compared with HOM. The ERM had a higher prevalence of severe hypogonadism as compared with the HOM.

Author List

Kosasih JB, Abbasi AA, Rudman D

Author

Judith B. Kosasih MD Professor in the Physical Medicine and Rehabilitation department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Hospitalization
Humans
Hypogonadism
Insulin-Like Growth Factor I
Male
Middle Aged
Rehabilitation
Rehabilitation Centers
Testosterone