Androgen receptors beyond prostate cancer: an old marker as a new target. Oncotarget 2015 Jan 20;6(2):592-603
Date
01/18/2015Pubmed ID
25595907Pubmed Central ID
PMC4359241DOI
10.18632/oncotarget.2831Scopus ID
2-s2.0-84921778182 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting.
Author List
Munoz J, Wheler JJ, Kurzrock RAuthor
Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiomarkers, Tumor
Disease Progression
Humans
Male
Molecular Targeted Therapy
Neoplasms
Prostatic Neoplasms
Receptors, Androgen