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Androgen receptors beyond prostate cancer: an old marker as a new target. Oncotarget 2015 Jan 20;6(2):592-603

Date

01/18/2015

Pubmed ID

25595907

Pubmed Central ID

PMC4359241

DOI

10.18632/oncotarget.2831

Scopus ID

2-s2.0-84921778182 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting.

Author List

Munoz J, Wheler JJ, Kurzrock R

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers, Tumor
Disease Progression
Humans
Male
Molecular Targeted Therapy
Neoplasms
Prostatic Neoplasms
Receptors, Androgen