Faculty Collaboration Database

Outcome analyses after the first admission to an intensive care unit in patients with advanced cancer referred to a phase I clinical trials program. J Clin Oncol 2011 Sep 10;29(26):3547-52

Date

08/17/2011

Pubmed ID

21844494

DOI

10.1200/JCO.2010.33.3823

Scopus ID

2-s2.0-80052979047 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

PURPOSE: This study assessed outcomes of individuals with advanced cancer who required admission to an intensive care unit (ICU) after referral for an early clinical trial because they did not respond to conventional therapy.

PATIENTS AND METHODS: Outcome analyses were conducted for 212 consecutive patients admitted to The University of Texas MD Anderson Cancer Center ICU after being seen in the phase I clinic starting on May 1, 2007. All data were obtained by a review of electronic medical records of patients.

RESULTS: The median survival of 212 patients with advanced cancer referred to phase I care after the initial ICU admission was 3.2 weeks (95% CI, 2.5 to 4.9 weeks). Patients who underwent cardiopulmonary resuscitation (CPR) succumbed within a median survival of 1 day (75% and 25% estimated survival of 1 and 3 days, respectively). Patients admitted for a postsurgical intervention did better than patients admitted for a nonsurgical intervention (median survival, 21.5 versus 2.1 weeks; P < .0001). The multivariate analysis revealed that a nonsurgical intervention, hypoalbuminemia, and higher Acute Physiology and Chronic Health Evaluation II scores were associated with poor overall survival.

CONCLUSION: The outcome of patients in a phase I clinic after initial ICU admission was poor, particularly when admission was for a nonsurgical intervention and/or when CPR was needed.

Author List

Fu S, Hong DS, Naing A, Wheler J, Falchook G, Wen S, Howard A, Barber D, Nates J, Price K, Kurzrock R

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Cardiopulmonary Resuscitation
Clinical Trials, Phase I as Topic
Critical Care
Female
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasms
Prognosis
Quality of Life
Referral and Consultation
Resuscitation Orders
Retrospective Studies
Risk Factors
Survival Analysis
Texas