Faculty Collaboration Database

Reproducibility of CT perfusion parameters in liver tumors and normal liver. Radiology 2011 Sep;260(3):762-70

Date

07/27/2011

Pubmed ID

21788525

Pubmed Central ID

PMC3156998

DOI

10.1148/radiol.11110331

Scopus ID

2-s2.0-84860389713 (requires institutional sign-in at Scopus site)   57 Citations

Abstract

PURPOSE: To assess the reproducibility of computed tomographic (CT) perfusion measurements in liver tumors and normal liver and effects of motion and data acquisition time on parameters.

MATERIALS AND METHODS: Institutional review board approval and written informed consent were obtained for this prospective study. The study complied with HIPAA regulations. Two CT perfusion scans were obtained 2-7 days apart in seven patients with liver tumors with two scanning phases (phase 1: 30-second breath-hold cine; phase 2: six intermittent free-breathing cines) spanning 135 seconds. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface area product (PS) for tumors and normal liver were calculated from phase 1 with and without rigid registration and, for combined phases 1 and 2, with manually and rigid-registered phase 2 images, by using deconvolution modeling. Variability was assessed with within-patient coefficients of variation (CVs) and Bland-Altman analyses.

RESULTS: For tumors, BF, BV, MTT, and PS values and reproducibility varied by analytical method, the former by up to 11%, 23%, 21%, and 138%, respectively. Median PS values doubled with the addition of phase 2 data to phase 1 data. The best overall reproducibility was obtained with rigidly registered phase 1 and phase 2 images, with within-patient CVs for BF, BV, MTT, and PS of 11.2%, 14.4%, 5.5% and 12.1%, respectively. Normal liver evaluations were similar, except with marginally lower variability.

CONCLUSION: Absolute values and reproducibility of CT perfusion parameters were markedly influenced by motion and data acquisition time. PS, in particular, probably requires data acquisition beyond a single breath hold, for which motion-correction techniques are likely necessary.

Author List

Ng CS, Chandler AG, Wei W, Herron DH, Anderson EF, Kurzrock R, Charnsangavej C

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Female
Gadolinium DTPA
Humans
Image Enhancement
Liver
Liver Diseases
Liver Function Tests
Liver Neoplasms
Magnetic Resonance Imaging
Male
Middle Aged
Perfusion Imaging
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed