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Reproducibility of perfusion parameters obtained from perfusion CT in lung tumors. AJR Am J Roentgenol 2011 Jul;197(1):113-21

Date

06/28/2011

Pubmed ID

21701018

DOI

10.2214/AJR.10.5404

Scopus ID

2-s2.0-79960530519 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

OBJECTIVE: The purpose of this article is to assess the variability of perfusion CT measurements in lung tumors and the effects of motion and duration of data acquisition on perfusion CT parameter values.

SUBJECTS AND METHODS: Two perfusion CT scans were obtained in 11 patients with lung tumors, 2-7 days apart, using phase 1 scans (30-second breath-hold cine) followed by phase 2 scans (six intermittent helical breath-holds), spanning 125 seconds. Tumor blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability were calculated for phase 1 using all-cine and motion-corrected (rigidly registered) images, both with and without matching phase 2 images (manually or rigidly registered). Variability was assessed by the within-patient coefficient of variation (CV) and Bland-Altman analyses.

RESULTS: BF, BV, MTT, and permeability values varied widely by method of analysis (median BF, 45.3-65.1 mL/min/100 g; median BV, 2.6-3.8 mL/100 g; median MTT, 3.6-4.1 seconds, and median permeability, 13.7-39.3 mL/min/100 g), as did within-patient CVs (10.9-114.4%, 25.3-117.6%, 22.3-51.5%, and 29.6-134.9%, respectively). Parameter values and variability were affected by motion and duration of data analyzed: permeability values doubled when phase 2 images were added to phase 1 data. Overall, the best reproducibility was obtained with registered phase 1 and 2 data, with within-patient CVs of 11.6%, 26.5%, 45.4%, and 30.2%, respectively.

CONCLUSION: The absolute values and reproducibility of perfusion parameters in lung tumors are markedly influenced by motion and duration of data acquisition. Permeability, in particular, probably requires data acquisition beyond a single breath-hold. The smallest variability in parameter values was obtained with motion correction and extended acquisition durations.

Author List

Ng CS, Chandler AG, Wei W, Anderson EF, Herron DH, Charnsangavej C, Kurzrock R

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Artifacts
Female
Humans
Lung Neoplasms
Male
Middle Aged
Perfusion Imaging
Pulmonary Circulation
Tomography, X-Ray Computed
Young Adult