Medical College of Wisconsin
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Chemotherapy resistance and retreatment: a dogma revisited. Clin Colorectal Cancer 2010 Apr;9(2):E1-4

Date

04/10/2010

Pubmed ID

20378496

DOI

10.3816/CCC.2010.n.026

Abstract

The prevailing belief in cancer therapy is that retreatment with a given drug after the emergence of resistance is ineffective. Herein, we report several cases in which retreatment with drugs that had failed earlier in the disease trajectory caused renewed tumor regression. The possible biologic underpinnings that might explain this phenomenon are discussed.

Author List

Naing A, Kurzrock R

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Adult
Antineoplastic Agents
Carcinoembryonic Antigen
Colorectal Neoplasms
Disease Progression
Drug Resistance, Neoplasm
Female
Humans
Liver Neoplasms
Male
Middle Aged
Treatment Failure