Chemotherapy resistance and retreatment: a dogma revisited. Clin Colorectal Cancer 2010 Apr;9(2):E1-4
Date
04/10/2010Pubmed ID
20378496DOI
10.3816/CCC.2010.n.026Abstract
The prevailing belief in cancer therapy is that retreatment with a given drug after the emergence of resistance is ineffective. Herein, we report several cases in which retreatment with drugs that had failed earlier in the disease trajectory caused renewed tumor regression. The possible biologic underpinnings that might explain this phenomenon are discussed.
Author List
Naing A, Kurzrock RAuthor
Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenocarcinomaAdult
Antineoplastic Agents
Carcinoembryonic Antigen
Colorectal Neoplasms
Disease Progression
Drug Resistance, Neoplasm
Female
Humans
Liver Neoplasms
Male
Middle Aged
Treatment Failure